Slc19a2^tm1Ejn
Targeted Allele Detail

Summary

• Symbol: Slc19a2^tm1Ejn
• Name: solute carrier family 19 (thiamine transporter), member 2; targeted mutation 1, Ellis J Neufeld
• MGI ID: MGI:3605162
• Synonyms: Slc19a2^-
• Gene: Slc19a2 Location: Chr1:164076615-164092954 bp, + strand Genetic Position: Chr1, 71.56 cM
• Alliance: Slc19a2^tm1Ejn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101675
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced sequence spanning from intron 2 to intron 5. Northern blot and RT-PCR confirmed absence of transcript in various tissues. (J:101675)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc19a2 Mutation: 33 strains or lines available

References

• Original: J:101675 Fleming JC, et al., Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab. 2003 Sep-Oct;80(1-2):234-41
• All: 3 reference(s)