Gria1^tm2Rlh
Targeted Allele Detail

Summary

• Symbol: Gria1^tm2Rlh
• Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 2, Richard L Huganir
• MGI ID: MGI:3605220
• Synonyms: GluR1delta7
• Gene: Gria1 Location: Chr11:56902342-57221070 bp, + strand Genetic Position: Chr11, 34.51 cM
• Alliance: Gria1^tm2Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101578
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A mutation introduced a seven amino acid deletion in exon 17, thereby removing the PDZ ligand. Protein was detected in mutants when raised by an antibody against the last 80 amino acids of the C terminus, however, not when raised by an antibody against the last 20 amino acids. (J:101578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria1 Mutation: 65 strains or lines available

References

• Original: J:101578 Kim CH, et al., Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1. Nat Neurosci. 2005 Aug;8(8):985-7
• All: 2 reference(s)