Nectin1^tm1Ytk
Targeted Allele Detail

Summary

• Symbol: Nectin1^tm1Ytk
• Name: nectin cell adhesion molecule 1; targeted mutation 1, Yoshimi Takai
• MGI ID: MGI:3605480
• Synonyms: nectin 1^-
• Gene: Nectin1 Location: Chr9:43655251-43718758 bp, + strand Genetic Position: Chr9, 24.42 cM, cytoband B
• Alliance: Nectin1^tm1Ytk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101707
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct was designed to replace sequence in exon 2 encoding amino acids 26-143 with a neomycin resistance gene. Absence of protein was confirmed by Western blot. (J:101707)

Disease models

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nectin1 Mutation: 23 strains or lines available

References

• Original: J:101707 Inagaki M, et al., Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development. 2005 Apr;132(7):1525-37
• All: 12 reference(s)