Prdm1^tm1Clme
Targeted Allele Detail

Summary

• Symbol: Prdm1^tm1Clme
• Name: PR domain containing 1, with ZNF domain; targeted mutation 1, Kathryn Calame
• MGI ID: MGI:3605621
• Synonyms: Blimp-1flox, Prdm1^CA, Prdm1^flox
• Gene: Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
• Alliance: Prdm1^tm1Clme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101890
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 6-8, encompassing sequence that encodes the zinc finger motifs. (J:101890)

Disease models

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prdm1 Mutation: 66 strains or lines available

References

• Original: J:101890 Shapiro-Shelef M, et al., Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity. 2003 Oct;19(4):607-20
• All: 117 reference(s)