Shox2^tm1Ypc
Targeted Allele Detail

Summary

• Symbol: Shox2^tm1Ypc
• Name: SHOX homeobox 2; targeted mutation 1, YiPing Chen
• MGI ID: MGI:3605739
• Synonyms: Shox2^-
• Gene: Shox2 Location: Chr3:66879060-66889104 bp, - strand Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
• Alliance: Shox2^tm1Ypc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101732
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced exon 3, which encodes the homeodomain. RT-PCR confirmed absence of expression in mutants. (J:101732)

Expression

In Mice Carrying this Mutation:	89 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shox2 Mutation: 20 strains or lines available

References

• Original: J:101732 Yu L, et al., Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development. 2005 Oct;132(19):4397-406
• All: 7 reference(s)