Adamts13^tm1Dgi
Targeted Allele Detail

Summary

• Symbol: Adamts13^tm1Dgi
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 13; targeted mutation 1, David Ginsburg
• MGI ID: MGI:3605825
• Synonyms: Adamts13^-
• Gene: Adamts13 Location: Chr2:26863428-26899640 bp, + strand Genetic Position: Chr2, 19.14 cM
• Alliance: Adamts13^tm1Dgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 1-6. RT-PCR of mutant liver samples confirmed absence of transcript. (J:101752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adamts13 Mutation: 70 strains or lines available

References

• Original: J:101752 Motto DG, et al., Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest. 2005 Oct;115(10):2752-61
• All: 37 reference(s)