Grm6^nob3
Spontaneous Allele Detail

Summary

• Symbol: Grm6^nob3
• Name: glutamate receptor, metabotropic 6; no b wave 3
• MGI ID: MGI:3605835
• Gene: Grm6 Location: Chr11:50741512-50757035 bp, + strand Genetic Position: Chr11, 30.93 cM
• Alliance: Grm6^nob3 page

Mutation origin

• Strain of Origin: C57BL/10

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A C-to-T transition occured spontaneously in intron 1. This results in a new splice donor site (G-GT from G-GC), which alters splicing and, together with an upstream cryptic splice donor CAG, inserts a new 65 bp exon between exons 1 and 2. This leads to a frame shift and premature termination. The absence of protein expression was confirmed by immunohistochemistry on the outer plexiform layer. (J:152828)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm6 Mutation: 53 strains or lines available

References

• Original: J:152828 Maddox DM, et al., Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses. J Physiol. 2008 Sep 15;586(Pt 18):4409-24
• All: 15 reference(s)