Vkorc1^L128S
Spontaneous Allele Detail

Summary

• Symbol: Vkorc1^L128S
• Name: vitamin K epoxide reductase complex, subunit 1; Leu128Ser
• MGI ID: MGI:3605979
• Gene: Vkorc1 Location: Chr7:127492235-127494789 bp, - strand Genetic Position: Chr7, 69.81 cM
• Alliance: Vkorc1^L128S page

Mutation origin

• Strain of Origin: wild

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• These mice contain a leucine to serine substitution at amino acid position 128. (J:101681)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vkorc1 Mutation: 7 strains or lines available

Notes

This colony of mice was from CSL in York, UK. A homozygous warfarin-resistant strain was derived by crossing mice of a warfarin-resistant PBI strain, directly descending from wild mice reported in 1976 by Wallace and MacSwiney (J:5635) with warfarin-susceptible mice of a LAC-gray strain. This may by identical to the War marker but analysis is not provided.

References

• Original: J:101681 Pelz HJ, et al., The genetic basis of resistance to anticoagulants in rodents. Genetics. 2005 Aug;170(4):1839-47
• All: 1 reference(s)