Vkorc1^Y139C
Spontaneous Allele Detail

Summary

• Symbol: Vkorc1^Y139C
• Name: vitamin K epoxide reductase complex, subunit 1; Tyr139Cys
• MGI ID: MGI:3605985
• Synonyms: MHR
• Gene: Vkorc1 Location: Chr7:127492235-127494789 bp, - strand Genetic Position: Chr7, 69.81 cM
• Alliance: Vkorc1^Y139C page

Mutation origin

• Strain of Origin: wild

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• These mice contain a tyrosine to cysteine substitution at amino acid position 139. (J:101681)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Vkorc1 Mutation: 7 strains or lines available

Notes

The Reading resistant mouse strain (MHR) was homozygous for a resistance gene that had been transferred through six generations onto the Reading susceptible mouse MHS background (C. V. Prescott, unpublished results). The mouse resistance gene was obtained from a wild population of house mice originally trapped near Reading, UK.

References

• Original: J:101681 Pelz HJ, et al., The genetic basis of resistance to anticoagulants in rodents. Genetics. 2005 Aug;170(4):1839-47
• All: 1 reference(s)