Mc5r^tm1Cone
Targeted Allele Detail

Summary

• Symbol: Mc5r^tm1Cone
• Name: melanocortin 5 receptor; targeted mutation 1, Roger D Cone
• MGI ID: MGI:3606007
• Synonyms: MC5-RKO
• Gene: Mc5r Location: Chr18:68470575-68475517 bp, + strand Genetic Position: Chr18, 41.46 cM
• Alliance: Mc5r^tm1Cone page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44727
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 650 bp fragment of the coding sequence was replaced with a PGK-neo by homologous recombination. Northern analysis of skeletal muscle confirmed absence of transcript in mutants. (J:44727)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc5r Mutation: 23 strains or lines available

References

• Original: J:44727 Chen W, et al., Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell. 1997 Dec 12;91(6):789-98
• All: 9 reference(s)