Cpt1a^tm1Pwo
Targeted Allele Detail

Summary

• Symbol: Cpt1a^tm1Pwo
• Name: carnitine palmitoyltransferase 1a, liver; targeted mutation 1, Philip A Wood
• MGI ID: MGI:3606251
• Synonyms: Cpt-1a^tm1Uab
• Gene: Cpt1a Location: Chr19:3372334-3435733 bp, + strand Genetic Position: Chr19, 3.08 cM
• Alliance: Cpt1a^tm1Pwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101934
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace exons 11-18 with a neomycin resistance gene in the reverse orientation to transcription. FISH confirmed correct targeting of the locus. (J:101934)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cpt1a Mutation: 57 strains or lines available

References

• Original: J:101934 Nyman LR, et al., Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse. Mol Genet Metab. 2005 Sep-Oct;86(1-2):179-87
• All: 3 reference(s)