About   Help   FAQ
Blmpf5C57BL/6J
QTL Variant Detail
Summary
QTL variant: Blmpf5C57BL/6J
Name: bleomycin-induced pulmonary fibrosis 5; C57BL/6J
MGI ID: MGI:3606269
QTL: Blmpf5  Location: unknown  Genetic Position: Chr18, cM position of peak correlated region/allele: 37.57 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:101567

Loci associated with susceptibility to bleomycin-induced pulmonary fibrosis were mapped using 36 recombinant congenic (RC) strains derived from C57BL/6J (susceptible) and A/J (resistant). Three to five animals of each recombinant congenic strain were exposed to bleomycin and phenotyped for lung fibrosis 3 weeks later.

Among the BcA (C57BL/6J x A/J) RC strains, significant linkage to bleomycin-induced pulmonary fibrosis susceptibility mapped to mouse Chromosomes 9, 15, and 18. These loci are described below. Among all RC strains tested, suggestive linkage to bleomycin-induced pulmonary fibrosis susceptibility mapped to mouse Chromosomes 1, 3, 5, 6, 9, and 12. C57BL/6J-derived alleles confer susceptibility to bleomycin-induced pulmonary fibrosis all suggestive loci, many of which are male-specific. Potential candidate genes were identified for suggestive QTL on mouse Chromosomes 1, 5, 6, and 12 using gene expression analysis of lung mRNA from bleomycin-treated A/J and C57BL/6J animals. (This data can be found on Table 4 of the publication.)

Blmpf3 (bleomycin-induced pulmonary fibrosis 3) mapped to 43 cM on mouse Chromosome 9 near D9Mit236 (LOD=4.92). A/J-derived alleles at Blmpf3 confer susceptibility to bleomycin-induced pulmonary fibrosis.

Blmpf4 (bleomycin-induced pulmonary fibrosis 4) mapped to 55.6 cM on mouse Chromosome 15 near D15Mit108 (LOD=3.51). A/J-derived alleles at Blmpf4 confer susceptibility to bleomycin-induced pulmonary fibrosis. Igta5 (57.4 cM), Irak4, and BC031593 are candidate genesidentified by gene expression analysis. Igta5 and Irak4 exhibit decreased expression in bleomycin-treated A/J animals, and BC031593 exhibits increased expression in lungs of bleomycin-treated A/J animals, compared to bleomycin-treated C57BL/6J.

Blmpf5 (bleomycin-induced pulmonary fibrosis 5) mapped to 37 cM on mouse Chromosome 18 near D18Mit183 (LOD=3.51). A/J-derived alleles at Blmpf5 confer susceptibility to bleomycin-induced pulmonary fibrosis. Lox (29 cM) and Iigp1 are candidate genes identified by gene expression analysis. Lox and Iigp1 expression both decreased in lungs of bleomycin-treated A/J animals, compared to bleomycin-treated C57BL/6J.

References
Original:  J:101567 Lemay AM, et al., Bleomycin-induced pulmonary fibrosis susceptibility genes in AcB/BcA recombinant congenic mice. Physiol Genomics. 2005 Sep 21;23(1):54-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory