Ccl24^tm1Mer
Targeted Allele Detail

Summary

• Symbol: Ccl24^tm1Mer
• Name: C-C motif chemokine ligand 24; targeted mutation 1, Marc E Rothenberg
• MGI ID: MGI:3606463
• Synonyms: eotaxin-2
• Gene: Ccl24 Location: Chr5:135598791-135601903 bp, - strand Genetic Position: Chr5, 75.28 cM, cytoband G1
• Alliance: Ccl24^tm1Mer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98708
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaces 1.86 kb of DNA containing all of exon 1 through exon 2 of the gene. Northern blot analysis of nine tissues demonstrated no detectable mRNA expression in homozygous mutants. ELISA detected no protein in bronchoalveolar lavage fluid of mutant mice. (J:98708, J:102034)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccl24 Mutation: 7 strains or lines available

References

• Original: J:98708 Pope SM, et al., Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. J Biol Chem. 2005 Apr 8;280(14):13952-61
• All: 8 reference(s)