Cpeb1^tm1Rcht
Targeted Allele Detail

Summary

• Symbol: Cpeb1^tm1Rcht
• Name: cytoplasmic polyadenylation element binding protein 1; targeted mutation 1, Joel D Richter
• MGI ID: MGI:3606747
• Synonyms: CREB^-
• Gene: Cpeb1 Location: Chr7:80996774-81105207 bp, - strand Genetic Position: Chr7, 45.71 cM
• Alliance: Cpeb1^tm1Rcht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102097
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced sequence including part of exon 3 and all of exons 4 and 5. RT-PCR and Western blot confirmed absence of transcript and protein, respectively, in mutant testes. (J:102097)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpeb1 Mutation: 22 strains or lines available

References

• Original: J:102097 Tay J, et al., Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice. Dev Cell. 2001 Aug;1(2):201-13
• All: 7 reference(s)