Acrbp^tm1Wen
Targeted Allele Detail

Summary

• Symbol: Acrbp^tm1Wen
• Name: proacrosin binding protein; targeted mutation 1, Wolfgang Engel
• MGI ID: MGI:3606887
• Synonyms: PRR^-
• Gene: Acrbp Location: Chr6:125026890-125040228 bp, + strand Genetic Position: Chr6, 59.17 cM, cytoband F2
• Alliance: Acrbp^tm1Wen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102079
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace the 224 bp fragment coding the proline-rich domain with a PGK-neo cassette. Northern blot of mutant testes did not detect the wild-type 1.6 kb transcript. (J:102079)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acrbp Mutation: 19 strains or lines available

References

• Original: J:102079 Nayernia K, et al., Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility. Mol Hum Reprod. 2002 May;8(5):434-40
• All: 1 reference(s)