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Acrbptm1Wen
Targeted Allele Detail
Summary
Symbol: Acrbptm1Wen
Name: proacrosin binding protein; targeted mutation 1, Wolfgang Engel
MGI ID: MGI:3606887
Synonyms: PRR-
Gene: Acrbp  Location: Chr6:125026890-125040228 bp, + strand  Genetic Position: Chr6, 59.17 cM, cytoband F2
Alliance: Acrbptm1Wen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102079
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed to replace the 224 bp fragment coding the proline-rich domain with a PGK-neo cassette. Northern blot of mutant testes did not detect the wild-type 1.6 kb transcript. (J:102079)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acrbp Mutation:  19 strains or lines available
References
Original:  J:102079 Nayernia K, et al., Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility. Mol Hum Reprod. 2002 May;8(5):434-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory