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Sox10df10R
Radiation induced Allele Detail
Summary
Symbol: Sox10df10R
Name: SRY (sex determining region Y)-box 10; df10R
MGI ID: MGI:3606975
Gene: Sox10  Location: Chr15:79039113-79048690 bp, - strand  Genetic Position: Chr15, 37.7 cM
Alliance: Sox10df10R page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102039
Parent Cell Line:  EC7.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129X1/SvJ)F1
Mutation
description
Allele Type:    Radiation induced (Not Applicable)
Mutations:    Deletion, Insertion
  Sox10df10R involves 1 genes/genome features (Sox10) View all
 
Mutation detailsAn HSV-tk/beta-actin-neo cassette was inserted into intron 3 using a gene targeting strategy. ES cells expressing both markers were selected. After X-irradiation of properly targeted ES cell lines with 400 rad, loss of tk expression was determined using FIAV. Cells no longer expressing tk were further tested for loss of neomycin expression. SSLP typing of polymorphic microsatellite markers determined that this allele contains an estimated deletion of 151 kb.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox10 Mutation:  33 strains or lines available
References
Original:  J:102039 Chick WS, et al., X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15. Mamm Genome. 2005 Sep;16(9):661-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory