Sox10^df8R
Radiation induced Allele Detail

Summary

• Symbol: Sox10^df8R
• Name: SRY (sex determining region Y)-box 10; df8R
• MGI ID: MGI:3606976
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^df8R page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102039
• Parent Cell Line: EC7.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129X1/SvJ)F1

Mutation description

• Allele Type: Radiation induced (Not Applicable)
• Mutations: Insertion, Intergenic deletion
• Mutation details: An HSV-tk/beta-actin-neo cassette was inserted into intron 3 using a gene targeting strategy. ES cells expressing both markers were selected. After X-irradiation of properly targeted ES cell lines with 400 rad, loss of tk expression was determined using FIAV. Cells no longer expressing tk were further tested for loss of neomycin expression. SSLP typing of polymorphic microsatellite markers determined that this allele contains a deletion of more than 577 kb.

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:102039 Chick WS, et al., X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15. Mamm Genome. 2005 Sep;16(9):661-71
• All: 1 reference(s)