Nr0b2^tm1Rus
Targeted Allele Detail

Summary

• Symbol: Nr0b2^tm1Rus
• Name: nuclear receptor subfamily 0, group B, member 2; targeted mutation 1, David W Russell
• MGI ID: MGI:3607116
• Synonyms: Shp^-
• Gene: Nr0b2 Location: Chr4:133280687-133283847 bp, + strand Genetic Position: Chr4, 66.25 cM
• Alliance: Nr0b2^tm1Rus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102129
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 1 to disrupt the locus, eliminating the required portions of the ligand binding and dimerization domains. Northern blot analysis of mutant liver failed to detect protein. (J:102129)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr0b2 Mutation: 17 strains or lines available

References

• Original: J:102129 Kerr TA, et al., Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell. 2002 Jun;2(6):713-20
• All: 3 reference(s)