Clip1^tm1.1Gal
Targeted Allele Detail

Summary

• Symbol: Clip1^tm1.1Gal
• Name: CAP-GLY domain containing linker protein 1; targeted mutation 1.1, Niels Galjart
• MGI ID: MGI:3607146
• Synonyms: GFP-CLIP-170
• Gene: Clip1 Location: Chr5:123715857-123822527 bp, - strand Genetic Position: Chr5, 63.06 cM
• Alliance: Clip1^tm1.1Gal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102107
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele contains a GFP fused in-frame to the endogenous coding sequence as a result of cre-mediated excision of a floxed neo. A protein of ~200 kDa was produced in mutants, larger than that of wild-type. (J:102107)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Clip1^tm1.1Gal/Clip1^tm1.1Gal	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
cellular	√
abnormal spermatid morphology	√
abnormal manchette morphology	√
reproductive system	√
abnormal spermatid morphology	√
abnormal manchette morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clip1 Mutation: 83 strains or lines available

References

• Original: J:102107 Akhmanova A, et al., The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Genes Dev. 2005 Oct 15;19(20):2501-15
• All: 3 reference(s)