Hrh2^tm1Yfks
Targeted Allele Detail

Summary

• Symbol: Hrh2^tm1Yfks
• Name: histamine receptor H2; targeted mutation 1, Yasushi Fukushima
• MGI ID: MGI:3607154
• Gene: Hrh2 Location: Chr13:54346148-54390199 bp, + strand Genetic Position: Chr13, 28.4 cM
• Alliance: Hrh2^tm1Yfks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102252
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted in reverse orientation to replace 2.0-kb of the coding exon. Northern blot of mutant gastric mucosa confirmed absence of mRNA. (J:102252)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hrh2 Mutation: 26 strains or lines available

References

• Original: J:102252 Fukushima Y, et al., Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice. Eur J Pharmacol. 2003 May 2;468(1):47-58
• All: 4 reference(s)