Mohg2^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Mohg2^CAST/EiJ
• Name: modifier of hg 2; CAST/EiJ
• MGI ID: MGI:3607569
• QTL: Mohg2 Location: unknown Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Heterozygosity at this locus confers increased growth trajectory in the presence of Socs2^hg. (J:102238)
• Inheritance: Other (see notes)

Notes

Mohg2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:102238

Modifiers of the Socs2^hg high growth mutation were mapped using F2 animals from a cross between C57BL/6J-Socs2^hg and CAST/EiJ. Parental strain C57BL/6J-Socs2^hg exhibits significantly increased growth trajectory after 3 weeks of age compared to CAST/EiJ. F2 animals either homozygous for Socs2^hg or the wild type allele were phenotyped from 2 - 9 weeks of age and 83 polymorphic markers were used for the genome scan.

A growth QTL mapped to mouse Chromosome 2 between D2Mit93 (46 cM) and D2Mit389 (50.3 cM). This locus interacts with the Socs2^hg mutation and is named Mohg1 (modifier of hg 1). C57BL/6J-derived alleles at Mohg1 confer increased growth trajectory in F2 mice homozygous for Socs2^hg with a dominant effect. There is evidence of multiple QTL on chromosome 2. Mohg1 maps near previously identified weight gain QTL Wg1 (31 cM) and Wg2 (61 cM).

Two growth QTL named Mohg2 (modifier of hg 2) and Mohg3 (modifier of hg 3) mapped to 3 cM and 37 cM on mouse Chromosome X, respectively. DXMit54 is the closest marker to Mohg2 and DXMit18 is the closest marker to Mohg3. Heterozygosity for CAST/EiJ- and C57BL/6J-derived alleles at Mohg2 confer increased growth trajectory in F2 animals homozygous for Socs2^hg with an additive effect. Heterozygosity at this locus also increases growth trajectory in wild type F2 animals. C57BL/6J-derived alleles at Mohg3 confer increased growth trajectory in F2 animals homozygous for Socs2^hg with a dominant effect.

References

• Original: J:102238 Wu R, et al., Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice. Genetics. 2005 Sep;171(1):239-49
• All: 1 reference(s)