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Mohg3C57BL/6J
QTL Variant Detail
Summary
QTL variant: Mohg3C57BL/6J
Name: modifier of hg 3; C57BL/6J
MGI ID: MGI:3607570
QTL: Mohg3  Location: unknown  Genetic Position: ChrX, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsThis allele confers increased growth trajectory in the presence of Socs2hg compared to CAST/EiJ. (J:102238)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:102238

Modifiers of the Socs2hg high growth mutation were mapped using F2 animals from a cross between C57BL/6J-Socs2hg and CAST/EiJ. Parental strain C57BL/6J-Socs2hg exhibits significantly increased growth trajectory after 3 weeks of age compared to CAST/EiJ. F2 animals either homozygous for Socs2hg or the wild type allele were phenotyped from 2 - 9 weeks of age and 83 polymorphic markers were used for the genome scan.

A growth QTL mapped to mouse Chromosome 2 between D2Mit93 (46 cM) and D2Mit389 (50.3 cM). This locus interacts with the Socs2hg mutation and is named Mohg1 (modifier of hg 1). C57BL/6J-derived alleles at Mohg1 confer increased growth trajectory in F2 mice homozygous for Socs2hg with a dominant effect. There is evidence of multiple QTL on chromosome 2. Mohg1 maps near previously identified weight gain QTL Wg1 (31 cM) and Wg2 (61 cM).

Two growth QTL named Mohg2 (modifier of hg 2) and Mohg3 (modifier of hg 3) mapped to 3 cM and 37 cM on mouse Chromosome X, respectively. DXMit54 is the closest marker to Mohg2 and DXMit18 is the closest marker to Mohg3. Heterozygosity for CAST/EiJ- and C57BL/6J-derived alleles at Mohg2 confer increased growth trajectory in F2 animals homozygous for Socs2hg with an additive effect. Heterozygosity at this locus also increases growth trajectory in wild type F2 animals. C57BL/6J-derived alleles at Mohg3 confer increased growth trajectory in F2 animals homozygous for Socs2hg with a dominant effect.

References
Original:  J:102238 Wu R, et al., Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice. Genetics. 2005 Sep;171(1):239-49
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory