Insig1^tm1.1Mbjg
Targeted Allele Detail

Summary

• Symbol: Insig1^tm1.1Mbjg
• Name: insulin induced gene 1; targeted mutation 1.1, Joseph L Goldstein
• MGI ID: MGI:3607577
• Synonyms: Insig1^-
• Gene: Insig1 Location: Chr5:28276410-28283660 bp, + strand Genetic Position: Chr5, 13.94 cM
• Alliance: Insig1^tm1.1Mbjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101203
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Insig1^tm1Mbjg with mice expressing cre in the germline created this allele in which exon 1 was deleted via cre-mediated recombination. (J:101203)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insig1 Mutation: 17 strains or lines available

References

• Original: J:101203 Engelking LJ, et al., Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005 Sep;115(9):2489-98
• All: 2 reference(s)