Tg(KRT14-Kitl)1Takk
Transgene Detail

Summary

• Symbol: Tg(KRT14-Kitl)1Takk
• Name: transgene insertion 1, Takahiro Kunisada
• MGI ID: MGI:3607790
• Synonyms: K14-Scf, Kitl-Tg, KRT14-Kitl, SCF-Tg, TG1, Tg(KRT14-itl)1Takk
• Transgene: Tg(KRT14-Kitl)1Takk Location: unknown
• Alliance: Tg(KRT14-Kitl)1Takk page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Kitl)1Takk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kitl (MGI:96974)

• The human cytokeratin 14 upstream region was used to drive expression of kit ligand. (J:49253)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Mc1r^e/Mc1r^e Xpc^tm1Brd/Xpc^tm1Brd Tg(KRT14-Kitl)1Takk/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL
cx2  Disease Model	Xpa^tm1Tnka/Xpa^tm1Tnka Tg(KRT14-Kitl)1Takk/?	involves: C57BL/6 * CBA * SJL
cx3	Mc1r^e/Mc1r^e Tg(KRT14-Kitl)1Takk/0	involves: C57BL/6 * SJL

Phenotypes:

Affected Systems	cx1	cx2	cx3
show or hide all annotated terms
growth/size/body	√
weight loss	√
integument	√	√
abnormal coat/hair pigmentation		√
thick epidermis	√
skin lesions	√
abnormal epidermal pigmentation		√
increased skin tumor incidence		√
neoplasm	√	√
increased metastatic potential		√
increased tumor incidence	√
increased skin tumor incidence		√
increased squamous cell carcinoma incidence	√
pigmentation		√	√
abnormal coat/hair pigmentation		√
abnormal epidermal pigmentation		√
abnormal melanogenesis			√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx2
skin melanoma IDs skin melanoma       DOID:8923 DOID:0050609 DOID:10043 DOID:10046 DOID:10051 DOID:10052 DOID:10055 DOID:8922 ICD10CM:C43.9 ICD9CM:172 ICD9CM:172.0 ICD9CM:172.2 ICD9CM:172.4 ICD9CM:172.5 ICD9CM:172.9 MESH:D000096142 NCI:C3510 OMIM:608035 OMIM:612263 UMLS_CUI:C0151779 Close	√

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT14-Kitl)1Takk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

(C57BL x SJL) F1 fertilized oocytes were microinjected with the vector.

References

• Original: J:49253 Kunisada T, et al., Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors. Development. 1998 Aug;125(15):2915-23
• All: 17 reference(s)