Ret^tm3(RET)Vpa
Targeted Allele Detail

Summary

• Symbol: Ret^tm3(RET)Vpa
• Name: ret proto-oncogene; targeted mutation 3, Vassilis Pachnis
• MGI ID: MGI:3607929
• Synonyms: Ret^9-Y1062F
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm3(RET)Vpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102170
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A cDNA fragment encoding the intracellular portion of the human RET9 isoform was fused in-frame with mouse exon 11 immediately downstream of the transmembrane domain-coding region. The inserted cDNA contained a Y1062F substitution and was followed by a floxed PGK-neo cassette. (J:102170)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:102170 Wong A, et al., Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol Cell Biol. 2005 Nov;25(21):9661-73
• All: 1 reference(s)