Slc7a11^tm1Hsat
Targeted Allele Detail

Summary

• Symbol: Slc7a11^tm1Hsat
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; targeted mutation 1, Hideyo Sato
• MGI ID: MGI:3608695
• Synonyms: xCT^-
• Gene: Slc7a11 Location: Chr3:50319385-50403947 bp, - strand Genetic Position: Chr3, 21.72 cM, cytoband D
• Alliance: Slc7a11^tm1Hsat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102902
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: GFP and a Neo cassette were introduced into exon 1 via homologous recombination. Crossing with Cre-recombinase-expressing mice removed the neo cassette. Northern blot analysis confirmed absence of mRNA in brain and thymus and peritoneal macrophages. (J:102902)

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc7a11 Mutation: 49 strains or lines available

References

• Original: J:102902 Sato H, et al., Redox imbalance in cystine/glutamate transporter-deficient mice. J Biol Chem. 2005 Nov 11;280(45):37423-9
• All: 26 reference(s)