Fut8^tm1Nta
Targeted Allele Detail

Summary

• Symbol: Fut8^tm1Nta
• Name: fucosyltransferase 8; targeted mutation 1, Naoyuki Taniguchi
• MGI ID: MGI:3608699
• Synonyms: Fut8^-
• Gene: Fut8 Location: Chr12:77284878-77522770 bp, + strand Genetic Position: Chr12, 35.46 cM
• Alliance: Fut8^tm1Nta page

Growth retardation in Fut8^tm1Nta/Fut8^tm1Nta mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102932
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the translation initiation site, was replaced with an IRES-LacZ-Neo-pA cassette. Northern blot analysis of lung and brain RNA confirmed absence of full-length mRNA. (J:102932)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fut8 Mutation: 37 strains or lines available

References

• Original: J:102932 Wang X, et al., Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6
• All: 23 reference(s)