Gjc1^tm2Kni
Targeted Allele Detail

Summary

• Symbol: Gjc1^tm2Kni
• Name: gap junction protein, gamma 1; targeted mutation 2, Kiyomasa Nishii
• MGI ID: MGI:3608701
• Synonyms: Cx45^flox type 1
• Gene: Gjc1 Location: Chr11:102690405-102710526 bp, - strand Genetic Position: Chr11, 66.48 cM
• Alliance: Gjc1^tm2Kni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103078
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The entire coding exon was flanked with loxP sites followed by an nls-LacZ. The original construct also included a floxed neo cassette. The presence or absence of this cassette does not alter the phenotype. (J:103078, J:231835)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjc1 Mutation: 33 strains or lines available

References

• Original: J:103078 Nishii K, et al., Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect. Cell Commun Adhes. 2003 Jul-Dec;10(4-6):365-9
• All: 2 reference(s)