Snapin^tm1Zhs
Targeted Allele Detail

Summary

• Symbol: Snapin^tm1Zhs
• Name: SNAP-associated protein; targeted mutation 1, Zu-Hang Sheng
• MGI ID: MGI:3608768
• Synonyms: snapin KO
• Gene: Snapin Location: Chr3:90395333-90398320 bp, - strand Genetic Position: Chr3, 39.24 cM
• Alliance: Snapin^tm1Zhs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102725
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All four coding exons were replaced by a PGKneo cassette via homologous recombination. Southern blot analysis revealed a novel 5.9 kb DNA fragment corresponding to the interrupted gene, however Western blot analysis confirmed absence of protein expression. (J:102725)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snapin Mutation: 13 strains or lines available

References

• Original: J:102725 Tian JH, et al., The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J Neurosci. 2005 Nov 9;25(45):10546-55
• All: 7 reference(s)