Cx3cr1^tm1Zm
Targeted Allele Detail

Summary

• Symbol: Cx3cr1^tm1Zm
• Name: C-X3-C motif chemokine receptor 1; targeted mutation 1, Ziad Mallat
• MGI ID: MGI:3608773
• Synonyms: CX3CR1 KO
• Gene: Cx3cr1 Location: Chr9:119877749-119897362 bp, - strand Genetic Position: Chr9, 71.37 cM
• Alliance: Cx3cr1^tm1Zm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103047
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 600 bp fragment, including the start codon and 382 bp of coding region, was replaced with a neo cassette via homologous recombination. (J:103047)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cx3cr1 Mutation: 45 strains or lines available

Notes

ES cell line = R1.211

References

• Original: J:103047 Combadiere C, et al., Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Circulation. 2003 Feb 25;107(7):1009-16
• All: 52 reference(s)