Aem1^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Aem1^C57BL/6
• Name: antierythrocyte autoantibody modifier 1; C57BL/6
• MGI ID: MGI:3608856
• QTL: Aem1 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to anti-erythrocyte autoantibody production compared to NZB. (J:7191)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7191

A population of (C57BL/6 x NZB)F1 x NZB backcross animals were analyzed for linkage to anti-erythrocyte autoantibody (AEA) production. Parental strain NZB exhibits AEA production starting at 4 months of age whereas parental strain C57BL/6 and F1 animals do not exhibit AEA production up to 13 months of age. A locus named Aem1 (anti-erythrocyte autoantibody modifier 1) mapped to mouse Chromosome 4 upstream of Mup1 (27.8 cM). C57BL/6J-derived alleles at Aem1 confer inhibition of AEA production with dominantinheritance. A potential candidate gene for Aem1 is Cd72 (22.5 cM, formerly Lyb2) but parental strain C57BL/6 and NZB were found to share the same allele at Cd72.

References

• Original: J:7191 Ozaki S, et al., Genetic regulation of erythrocyte autoantibody production in New Zealand black mice. Immunogenetics. 1983;18(3):241-54
• All: 1 reference(s)