Anth^C3H/HeNCrj
QTL Variant Detail

Summary

• QTL variant: Anth^C3H/HeNCrj
• Name: resistance to Bacillus anthracis; C3H/HeNCrj
• MGI ID: MGI:3608860
• QTL: Anth Location: unknown

Variant origin

• Strain of Specimen: C3H/HeNCrj

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to B. anthracis compared to C57BL/6NCrj. (J:11149)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:11149

A population of female backcross animals derived from C3H/HeNCrj and C57BL/6NCrj was analyzed for resistance to Bacillus anthracis. Parental strain C3H/HeNCrj is resistant (12% mortality rate) compared toparental strain C57BL/6NCrj (84% mortality rate). A C3H/HeNCrj-derived locus named Anth is believed to confer resistance to B. anthracis with dominant inheritance.

References

• Original: J:11149 Shibaya M, et al., The genetic basis of host resistance to Bacillus anthracis in inbred mice. Vet Microbiol. 1991 Feb 1;26(3):309-12
• All: 1 reference(s)