Pcts^DBA/2N
QTL Variant Detail

Summary

• QTL variant: Pcts^DBA/2N
• Name: plasmacytoma susceptibility; DBA/2N
• MGI ID: MGI:3608870
• QTL: Pcts Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DBA/2N

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:15235

In an intraspecific backcross BALB/cAnPt females x (BALB/cAnPt x DBA/2N)F1 males, where BALB/cAnPt is susceptible to plasmacytoma tumors and the F1 hybrid strain is resistant, 83 out of 773 progeny developed tumors suggesting a multiple trait inheritance. The initial 28 progeny tested for Pcts1 showed significant Chi square values with Chromosome 4 markers Ifa, Mtv13 and Nppa; the progeny also being homozygous susceptible BALB/cAnPt. Further analysis of 77 susceptible backcross progeny gave 9 recombinants between Pcts1 and Gt10 suggesting a distance within 11.6 +/- 3.6 cM between the two.

Homozygosity for BALB/cAnPt-derived alleles is associated with sussceptibility to pristane-induced plasmacytomas.

References

• Original: J:15235 Mock BA, et al., Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9499-503
• All: 1 reference(s)