Pctm^DBA/2N
QTL Variant Detail

Summary

• QTL variant: Pctm^DBA/2N
• Name: plasmacytoma modifier; DBA/2N
• MGI ID: MGI:3608873
• QTL: Pctm Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DBA/2N

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to pristane-induced plasmacytomas compared to BALB/cAnPt. (J:15235)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:15235

Chi square values for mice derived in the intraspecific backcross BALB/cAnPt females x (BALB/cAnPt x DBA/2N)F1 males indicate a potential linkage between Pcts2 and Chromosome 1 marker Fcgr2. Additional markers need to be tested to confirm/reject linkage.

Heterozygosity at Pctm is associated with susceptibility to pristane-induced plasmacytomas, whereas homozygosity for BALB/cAnPt-derived alleles at this locus is associated with resistance.

References

• Original: J:15235 Mock BA, et al., Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9499-503
• All: 1 reference(s)