Mkks^{Gt(OST367255)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Mkks^{Gt(OST367255)Lex}
• Name: McKusick-Kaufman syndrome; gene trap OST367255, Lexicon Genetics
• MGI ID: MGI:3608879
• Synonyms: Bbs6^-, Mkks^-, Mkks^{Gt(Betageo-BTK)705Lex}
• Gene: Mkks Location: Chr2:136715700-136733309 bp, - strand Genetic Position: Chr2, 67.64 cM
• Alliance: Mkks^{Gt(OST367255)Lex} page

Mutation origin

• Mutant Cell Line: OST367255
• Germline Transmission: Earliest citation of germline transmission: J:102697
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector consisting of LTR sites flanking a Beta-geo cassette containing a splice acceptor integrated into the intron between exon 1 and 2. RT-PCR confirmed absence of RNA. (J:102697)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST367255	CG638190 ; (MGI Seq Detail)	3' RACE	Chr2:136723326-136727621 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mkks Mutation: 27 strains or lines available

References

• Original: J:102697 Ross AJ, et al., Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet. 2005 Oct;37(10):1135-40
• All: 7 reference(s)