Yap1^tm1Smil
Targeted Allele Detail

Summary

• Symbol: Yap1^tm1Smil
• Name: yes-associated protein 1; targeted mutation 1, Sharon L Milgram
• MGI ID: MGI:3608880
• Synonyms: Yap^tm1Smil
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^tm1Smil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102253
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting event replaced approximately 1 kb of the gene, including the translation initiation site and all but 10 bp of exon 1, with a floxed MC1-neo cassette in reverse orientation. Western blot analysis of lysates of whole E8.5 embryos using affinity-purified antiserum to the C-terminus of human YAP protein produced no signal. (J:102253)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	11 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 38 strains or lines available

References

• Original: J:102253 Morin-Kensicki EM, et al., Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of yap65. Mol Cell Biol. 2006 Jan;26(1):77-87
• All: 6 reference(s)