Tg(Fabp4-Agt)2Mte
Transgene Detail

Summary

• Symbol: Tg(Fabp4-Agt)2Mte
• Name: transgene insertion 2, Michele Teboul
• MGI ID: MGI:3608886
• Transgene: Tg(Fabp4-Agt)2Mte Location: unknown
• Alliance: Tg(Fabp4-Agt)2Mte page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-Agt)2Mte expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Agt (24179)

  Agt	(MGI:87963)

• Mutation details: This transgene overexpresses the rat Agt gene under the control of the adipocyte-specific Fabp4 promoter. Northern blot and RT-PCR analysis indicates Agt expression specifically in adipose tissue with small amounts of mRNA detected in muscle and heart and none in liver or kidney. Several lines were made, with this line (Line 2) expressing the highest levels of Agt. (J:73163)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73163 Massiera F, et al., Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 2001 Dec;15(14):2727-9
• All: 3 reference(s)