Map3k7^Gt(XB444)Byg
Gene trapped Allele Detail

Summary

• Symbol: Map3k7^Gt(XB444)Byg
• Name: mitogen-activated protein kinase kinase kinase 7; gene trap XB444, BayGenomics
• MGI ID: MGI:3608889
• Synonyms: Map3k7^{Gt(Betageo-ALPP)1Byg}, TAK1^-
• Gene: Map3k7 Location: Chr4:31964097-32023467 bp, + strand Genetic Position: Chr4, 13.91 cM
• Alliance: Map3k7^Gt(XB444)Byg page

Mutation origin

• Mutant Cell Line: XB444
• Germline Transmission: Earliest citation of germline transmission: J:102721
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Baygenomics ES cell line XB444 (currently unavailable from Baygenomics) contains a gene trap vector inserted in intron 1. The vector includes a Beta geo fusion gene, an IRES, and the human placental alkaline phosphatase gene (ALPP). The insertion site was confirmed by the authors by PCR genotyping. Absence of gene product was confirmed by immunoblot analysis. (J:102721)

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k7 Mutation: 54 strains or lines available

References

• Original: J:102721 Shim JH, et al., TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005 Nov 15;19(22):2668-81
• All: 5 reference(s)