Sh3glb1^tm1Hgw
Targeted Allele Detail

Summary

• Symbol: Sh3glb1^tm1Hgw
• Name: SH3-domain GRB2-like B1 (endophilin); targeted mutation 1, Hong-Gang Wang
• MGI ID: MGI:3608890
• Synonyms: bif-1^-
• Gene: Sh3glb1 Location: Chr3:144389439-144426096 bp, - strand Genetic Position: Chr3, 69.0 cM
• Alliance: Sh3glb1^tm1Hgw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102178
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace exon 1 and the translation start site. Immunoblots of whole cell lysates confirmed absence of protein in mutant embryos. (J:102178)

Expression

In Mice Carrying this Mutation:

16 assay results

Tumor Data

List all tumor models in MMHCdb carrying Sh3glb1^tm1Hgw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sh3glb1 Mutation: 19 strains or lines available

References

• Original: J:102178 Takahashi Y, et al., Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol. 2005 Nov;25(21):9369-82
• All: 8 reference(s)