Ap2m1^tm1Ohno
Targeted Allele Detail

Summary

• Symbol: Ap2m1^tm1Ohno
• Name: adaptor-related protein complex 2, mu 1 subunit; targeted mutation 1, Hiroshi Ohno
• MGI ID: MGI:3608896
• Synonyms: mu2^-
• Gene: Ap2m1 Location: Chr16:20354230-20363659 bp, + strand Genetic Position: Chr16, 12.46 cM, cytoband 16
• Alliance: Ap2m1^tm1Ohno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102181
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene in reverse orientation replaced exons 3-11. Western blot indicated a decreased amount of protein in heterozygous MEFs. (J:102181)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ap2m1 Mutation: 42 strains or lines available

References

• Original: J:102181 Mitsunari T, et al., Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol. 2005 Nov;25(21):9318-23
• All: 1 reference(s)