Sox9^tm3(cre)Crm
Targeted Allele Detail

Summary

• Symbol: Sox9^tm3(cre)Crm
• Name: SRY (sex determining region Y)-box 9; targeted mutation 3, Benoit de Crombrugghe
• MGI ID: MGI:3608931
• Synonyms: Sox9-Cre, Sox9-IRES-Cre
• Gene: Sox9 Location: Chr11:112673050-112678586 bp, + strand Genetic Position: Chr11, 77.27 cM
• Alliance: Sox9^tm3(cre)Crm page

Rib fusion phenotype is enhanced in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice by loss of Gnai2 in cartilage

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102495
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Sox9^tm3(cre)Crm expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox9 (MGI:98371)

• Mutation details: An IRES-Cre-pA sequence with an FRT-flanked PGK-neo-bpA cassette was inserted into the 3' UTR in exon 3. (J:102495)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox9 (mouse) Summary of all recombinase alleles driven by Sox9. Alliance mouse Sox9 gene page

Disease models

Expression

In Mice Carrying this Mutation:

75 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox9 Mutation: 33 strains or lines available

References

• Original: J:102495 Akiyama H, et al., Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70
• All: 41 reference(s)