Men1^tm1Mmey
Targeted Allele Detail

Summary

• Symbol: Men1^tm1Mmey
• Name: multiple endocrine neoplasia 1; targeted mutation 1, Matthew Meyerson
• MGI ID: MGI:3608952
• Synonyms: Men1^-
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm1Mmey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88588
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting construct was designed to remove exons 3-6 using cre-mediated recombination, leading to a frameshift causing a premature stop codon in exon 7. This allele was generated using Men1^tm2.1Mmey. (J:88588)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:88588 Hughes CM, et al., Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell. 2004 Mar 27;13(4):587-97
• All: 3 reference(s)