Mrtfb^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Mrtfb^tm1Eno
• Name: myocardin related transcription factor B; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3608959
• Synonyms: MRTF-B^-
• Gene: Mrtfb Location: Chr16:13074345-13235393 bp, + strand Genetic Position: Chr16, 9.24 cM
• Alliance: Mrtfb^tm1Eno page

Branchial arch artery abnormalities in Mrtfb^tm1Eno/Mrtfb^tm1Eno embryos

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to delete exon 8 by the introduction of a lacZ and neomycin resistance cassette. Deletion of exon 8 results in a truncated protein containing only the first 270 amino acids of the protein and lacking the SRF-binding, dimerization, and transcription activation domains. The mutated protein is functionally intert. (J:102475)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrtfb Mutation: 68 strains or lines available

References

• Original: J:102475 Oh J, et al., Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15122-7
• All: 2 reference(s)