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Dxcp1C57BL/10SnJ
QTL Variant Detail
Summary
QTL variant: Dxcp1C57BL/10SnJ
Name: dexamethasone induced cleft palate 1; C57BL/10SnJ
MGI ID: MGI:3608996
QTL: Dxcp1  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  C57BL/10SnJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to dexamethasone-induced cleft palate compared to A/WySnJ. (J:6974)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7547

Statistical analysis with various inbred, backcross and H2 congenic mice were used to demonstrate that Dxcp1, Dxcp2 and Dxcp3 map to the H2 region of Chromosome 17. In a two locus model Dxcp1 was shown to map to H2-Eb1 and Dxcp2 mapped between the S and D region. A three locus model was proposed in which Dxcp1 mapped from the centromere to H2-Eb1 and Dxcp3 mapped proximal to Pgk1 and distal to the S region.

J:6974

Susceptibility to dexamethasone-induced cleft palate mapped to the H2 locus on mouse Chromosome 17 in a population of (B10.A/SgSnJ x C57BL/10/SnJ)F1 x C57BL/10/SnJ backcross animals. These loci are named Dxcp1 (19.5 cM) and Dxcp2 (18.975 cM). The A/WySnJ-derived allele (H2a) from B10.A/SgSnJ is associated with susceptibility to dexamethasone-induced cleft palate whereas the C57BL/10SnJ-derived allele (H2b) is associated with resistance. Heterozygous backcross animals exhibit a 28.9% incidence of dexamethasone-induced cleft palate compared to 11.9% in animals homozygous for C57BL/10SnJ-derived alleles at the H2 locus.

References
Original:  J:6974 Bonner JJ, et al., Backcross test demonstrates the linkage of glucocorticoid-induced cleft palate susceptibility to H-2. Teratology. 1982 Oct;26(2):213-6
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory