Summary |
|
|||||||||||||
Variant origin |
|
|||||||||||||
Variant description |
|
|||||||||||||
Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
|
|||||||||||||
Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:7547Statistical analysis with various inbred, backcross and H2 congenic mice were used to demonstrate that Dxcp1, Dxcp2 and Dxcp3 map to the H2 region of Chromosome 17. In a two locus model Dxcp1 was shown to map to H2-Eb1 and Dxcp2 mapped between the S and D region. A three locus model was proposed in which Dxcp1 mapped from the centromere to H2-Eb1 and Dxcp3 mapped proximal to Pgk1 and distal to the S region. J:6974Susceptibility to dexamethasone-induced cleft palate mapped to the H2 locus on mouse Chromosome 17 in a population of (B10.A/SgSnJ x C57BL/10/SnJ)F1 x C57BL/10/SnJ backcross animals. These loci are named Dxcp1 (19.5 cM) and Dxcp2 (18.975 cM). The A/WySnJ-derived allele (H2a) from B10.A/SgSnJ is associated with susceptibility to dexamethasone-induced cleft palate whereas the C57BL/10SnJ-derived allele (H2b) is associated with resistance. Heterozygous backcross animals exhibit a 28.9% incidence of dexamethasone-induced cleft palate compared to 11.9% in animals homozygous for C57BL/10SnJ-derived alleles at the H2 locus. |
|||||||||||||
References |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/29/2024 MGI 6.24 |
|
|