About   Help   FAQ
Dxcp1C57BL/10SnJ
QTL Variant Detail
Summary
QTL variant: Dxcp1C57BL/10SnJ
Name: dexamethasone induced cleft palate 1; C57BL/10SnJ
MGI ID: MGI:3608996
QTL: Dxcp1  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  C57BL/10SnJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to dexamethasone-induced cleft palate compared to A/WySnJ. (J:6974)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7547

Statistical analysis with various inbred, backcross and H2 congenic mice were used to demonstrate that Dxcp1, Dxcp2 and Dxcp3 map to the H2 region of Chromosome 17. In a two locus model Dxcp1 was shown to map to H2-Eb1 and Dxcp2 mapped between the S and D region. A three locus model was proposed in which Dxcp1 mapped from the centromere to H2-Eb1 and Dxcp3 mapped proximal to Pgk1 and distal to the S region.

J:6974

Susceptibility to dexamethasone-induced cleft palate mapped to the H2 locus on mouse Chromosome 17 in a population of (B10.A/SgSnJ x C57BL/10/SnJ)F1 x C57BL/10/SnJ backcross animals. These loci are named Dxcp1 (19.5 cM) and Dxcp2 (18.975 cM). The A/WySnJ-derived allele (H2a) from B10.A/SgSnJ is associated with susceptibility to dexamethasone-induced cleft palate whereas the C57BL/10SnJ-derived allele (H2b) is associated with resistance. Heterozygous backcross animals exhibit a 28.9% incidence of dexamethasone-induced cleft palate compared to 11.9% in animals homozygous for C57BL/10SnJ-derived alleles at the H2 locus.

References
Original:  J:6974 Bonner JJ, et al., Backcross test demonstrates the linkage of glucocorticoid-induced cleft palate susceptibility to H-2. Teratology. 1982 Oct;26(2):213-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory