Dxcp1^A/WySnJ
QTL Variant Detail

Summary

• QTL variant: Dxcp1^A/WySnJ
• Name: dexamethasone induced cleft palate 1; A/WySnJ
• MGI ID: MGI:3608997
• QTL: Dxcp1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: A/WySnJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to dexamethasone-induced cleft palate compared to C57BL/10SnJ. (J:6974)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7547

Statistical analysis with various inbred, backcross and H2 congenic mice were used to demonstrate that Dxcp1, Dxcp2 and Dxcp3 map to the H2 region of Chromosome 17. In a two locus model Dxcp1 was shown to map to H2-Eb1 and Dxcp2 mapped between the S and D region. A three locus model was proposed in which Dxcp1 mapped from the centromere to H2-Eb1 and Dxcp3 mapped proximal to Pgk1 and distal to the S region.

J:6974

Susceptibility to dexamethasone-induced cleft palate mapped to the H2 locus on mouse Chromosome 17 in a population of (B10.A/SgSnJ x C57BL/10/SnJ)F1 x C57BL/10/SnJ backcross animals. These loci are named Dxcp1 (19.5 cM) and Dxcp2 (18.975 cM). The A/WySnJ-derived allele (H2^a) from B10.A/SgSnJ is associated with susceptibility to dexamethasone-induced cleft palate whereas the C57BL/10SnJ-derived allele (H2^b) is associated with resistance. Heterozygous backcross animals exhibit a 28.9% incidence of dexamethasone-induced cleft palate compared to 11.9% in animals homozygous for C57BL/10SnJ-derived alleles at the H2 locus.

References

• Original: J:6974 Bonner JJ, et al., Backcross test demonstrates the linkage of glucocorticoid-induced cleft palate susceptibility to H-2. Teratology. 1982 Oct;26(2):213-6
• All: 1 reference(s)