Dxcp2^A/WySnJ
QTL Variant Detail

Summary

• QTL variant: Dxcp2^A/WySnJ
• Name: dexamethasone induced cleft palate 2; A/WySnJ
• MGI ID: MGI:3609001
• QTL: Dxcp2 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: A/WySnJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to dexamethasone-induced cleft palate compared to A/WySnJ. (J:6974)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7547

Statistical analysis with various inbred, backcross and H2 congenic mice were used to demonstrate that Dxcp1, Dxcp2 and Dxcp3 map to the H2 region of Chromosome 17. In a two locus model Dxcp1 was shown to map to H2-Eb1 and Dxcp2 mapped between the S and D region. A three locus model was proposed in which Dxcp1 mapped from the centromere to H2-Eb1 and Dxcp3 mapped proximal to Pgk1 and distal to the S region.

J:15971

QTL Reference Notes

Authors use Bat2, Bat3, Bat4 and Bat5 for D17H6S51E, D17H6S52E, D17H6S54E and D17H6S82E, respectively.

Using overlapping cosmid clones, the authors were able to order the following loci on a 280kb segment in the H2 region on mouse Chromosome 17; Zbtb12, Bat8, Neu1, Hspa1b, Hspa1a, Hspa1l, vars2, Bat5, Bat4, Bat3 and Bat2 Using recombinant congenic strains and susceptibility tests for cleft palate, authors were also able to confirm linkage with Dxcp2 and the H2 region, localizing it between Hspa1b and Bat6.

J:6974

Susceptibility to dexamethasone-induced cleft palate mapped to the H2 locus on mouse Chromosome 17 in a population of (B10.A/SgSnJ x C57BL/10/SnJ)F1 x C57BL/10/SnJ backcross animals. These loci are named Dxcp1 (19.5 cM) and Dxcp2 (18.975 cM). The A/WySnJ-derived allele (H2^a) from B10.A/SgSnJ is associated with susceptibility to dexamethasone-induced cleft palate whereas the C57BL/10SnJ-derived allele (H2^b) is associated with resistance. Heterozygous backcross animals exhibit a 28.9% incidence of dexamethasone-induced cleft palate compared to 11.9% in animals homozygous for C57BL/10SnJ-derived alleles at the H2 locus.

References

• Original: J:6974 Bonner JJ, et al., Backcross test demonstrates the linkage of glucocorticoid-induced cleft palate susceptibility to H-2. Teratology. 1982 Oct;26(2):213-6
• All: 1 reference(s)