Tg(F2RL1)1Mslb
Transgene Detail

Summary

• Symbol: Tg(F2RL1)1Mslb
• Name: transgene insertion 1, Mary Stevens
• MGI ID: MGI:3609028
• Synonyms: PAR2tg, Tg(F2RL1)1Nwb
• Transgene: Tg(F2RL1)1Mslb Location: unknown
• Alliance: Tg(F2RL1)1Mslb page

Transgene origin

• Strain of Origin: FVB/NCrl

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(F2RL1)1Mslb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  F2RL1 (2150)

  F2rl1

  (MGI:101910)

• Mutation details: The transgene comprises the entire human gene, including the promoter and at least 30 kb of flanking genomic DNA, from the BAC clone 23C20. The number of integrated copies, based on Southern blot analysis, is between between 5 and 10 per diploid genome. Northern blot analysis revealed high levels of transgene-derived mRNA in liver, skin, and spleen and lower levels in lung, heart and testis. (J:79757)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:79757 Schmidlin F, et al., Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J Immunol. 2002 Nov 1;169(9):5315-21
• All: 2 reference(s)