Lyr^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Lyr^BALB/cHeA
• Name: lymphoma resistance; BALB/cHeA
• MGI ID: MGI:3609032
• QTL: Lyr Location: Chr4:80752445-88769188 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to radiation-induced lymphomas compared to STS/A. (J:10558)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:10558

Linkage analysis was performed on a series of 12 CXS (C=BALB/cHeA; S=STS/A) recombinant inbred (RI) strains to identify loci associated with resistance to radiation-induced lymphomas. Parental strain BALB/cHeA is highly susceptible (77% lymphoma incidence) whereas parental strain STS/A is highly resistant (8% lymphoma incidence). Animals were treated with 4 doses of 1.7 Gy X-rays at weekly intervals starting at 4 weeks of age. Animals were followed up to 365 after the last radiation treatment. 80 polymorphic markers were used for the genetic analysis.

Resistance to radiation-induced lymphomas mapped to a region on mouse Chromosome 4 between Tyrp1 (38 cM) and Ifna (42.6 cM). This locus is named Lyr (lymphoma resistance.) BALB/cHeA-derived alleles at Lyr is associated with resistance to radiation-induced lymphomas.

References

• Original: J:10558 Okumoto M, et al., Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice. Cancer Res. 1990 Jul 1;50(13):3848-50
• All: 1 reference(s)