Igh^tm3.1Tim
Targeted Allele Detail

Summary

• Symbol: Igh^tm3.1Tim
• Name: immunoglobulin heavy chain complex; targeted mutation 3.1, Tim Manser
• MGI ID: MGI:3609137
• Synonyms: HK171Neo^-
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102308
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• A floxed neomycin resistance cassette was removed from Igh^tm3Tim. (J:102308)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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ht1	Igh^tm3.1Tim/Igh^+	involves: 129 * C57BL/6

Phenotypes:

Affected Systems	ht1
show or hide all annotated terms
hematopoietic system	√
abnormal B cell differentiation	√
abnormal bone marrow cell number	√
abnormal spleen B cell follicle morphology	√
immune system	√
abnormal B cell differentiation	√
abnormal spleen B cell follicle morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 39 strains or lines available

References

• Original: J:102308 Heltemes-Harris L, et al., An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol. 2005 Nov;17(11):1447-61
• All: 1 reference(s)