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Msmr1MSM/Ms
QTL Variant Detail
Summary
QTL variant: Msmr1MSM/Ms
Name: MSM lymphoma resistance 1; MSM/Ms
MGI ID: MGI:3609166
QTL: Msmr1  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  MSM/Ms
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This locus confers lymphoma resistance compared to SL/Kh. (J:34941)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:34941

All the chromosomes of progeny from a (MSM/Ms x SL/Kh)F1 x SL/Kh backcross were scanned for linkage of lymphoma susceptibility with 79 polymorphic microsatellite loci spaced 15 cM - 30 cM apart. Authors found a significant linkage disequilibrium in the proximal segment of mouse Chromosome 17, between D17Mit44 (11 cM) and D17Mit150 (33.3 cM). These data map Msmr1 between D17Mit44 and D17Mit150 on mouse Chromosome 17. The MSM/Ms-derived allele at Msmr1 is associated with dominant lymphoma resistance whereas the SL/Kh-derived allele is associated with susceptibility. Several host resistance loci map near Msmr1, such as Rfv1 (19.5 cM), Rgv1 (19.5 cM), Rmv1 (19.5 M), Rrv1 (19.5 cM), Rrsv (19.5 cM), and H2-Bf (18.85 cM).

References
Original:  J:34941 Pataer A, et al., Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15;56(16):3716-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory