Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:34941All the chromosomes of progeny from a (MSM/Ms x SL/Kh)F1 x SL/Kh backcross were scanned for linkage of lymphoma susceptibility with 79 polymorphic microsatellite loci spaced 15 cM - 30 cM apart. Authors found a significant linkage disequilibrium in the proximal segment of mouse Chromosome 17, between D17Mit44 (11 cM) and D17Mit150 (33.3 cM). These data map Msmr1 between D17Mit44 and D17Mit150 on mouse Chromosome 17. The MSM/Ms-derived allele at Msmr1 is associated with dominant lymphoma resistance whereas the SL/Kh-derived allele is associated with susceptibility. Several host resistance loci map near Msmr1, such as Rfv1 (19.5 cM), Rgv1 (19.5 cM), Rmv1 (19.5 M), Rrv1 (19.5 cM), Rrsv (19.5 cM), and H2-Bf (18.85 cM). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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